PROPECIA HAIR LOSS TABLETS
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and stop hair loss. Propecia, the only medically approved oral
prescription hair loss medication. Prescription Propecia has been shown
in numerous clinical studies to be the most effective hair loss
treatment yet available for stopping potential hair loss while
promoting hair re-growth.
What is Propecia?
Propecia® (Finasteride), available in the UK since 1997, is the first
and only oral medication approved by both the M.C.A. and the F.D.A. for
the treatment of male pattern hair loss. Effective in around 99% of
male patients at preventing further hair loss as well generating new
growth on both the vertex and the anterior mid-scalp areas.
The longest controlled clinical trial of a hair loss treatment ever
reported showed that men who took Propecia® (finasteride 1 mg) compared
to men who took a placebo had a considerable difference in their hair
counts after five years, according to data presented at the 59th
Annual Meeting of the American Academy of Dermatology.
The new study showed a difference of 277 hairs in a one-inch diameter
circle of scalp in favor of men treated with Propecia for five years
(n=219) vs. those who received a placebo (n=15). Baseline hair counts
of all men at the start of the study averaged 876 hairs in the one-inch
diameter circle.
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“This study provides new, long-term scientific data that Propecia
helped the majority of men with male pattern baldness keep the amount
of hair they have,” said Keith Kaufman, M.D., senior director, Clinical
Research, Merck Research Laboratories. “The study was also the first
controlled clinical trial to evaluate the course of untreated hair loss
over a five-year period and to show the progressive nature of male
pattern hair loss.”
APPROVED WORLDWIDE FOR THE TREATMENT OF HAIR LOSS
Made by Merck & Co., Inc., Propecia is indicated for the treatment
of certain types of hair loss in men only, based upon studies. Propecia
is a once-a-day treatment and is the only pill for male pattern hair
loss approved for use world wide. The five-year data are from
investigational extension studies of double- blind placebo-controlled
clinical trials that first demonstrated the safety and efficacy of
Propecia in 1,553 men age 18 to 41 with mild-to-moderate male pattern
baldness (androgentic alopecia) in the vertex region (top of the head).
Efficacy in bi-temporal recession (hair loss at the temples) has not
been established.
Men who entered the initial year long studies of Propecia were
randomized to receive either Propecia (n=779) or placebo (n=774). The
initial year long studies were extended on an annual basis, with only a
small number of men remaining on placebo in subsequent years, as
specified in the study design. Men who completed each one-year
extension were given the opportunity to enroll in the next one-year
extension, for up to five years. The five-year data presented focused
on the results of men who continued on the same therapy—either Propecia
or placebo—for the entire five years.
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Five-year Propecia efficacy results
The studies assessed the efficacy of Propecia by four separate
endpoints: hair counts in a one-inch diameter circle of the scalp;
assessments of “before” and “after” photographs by a panel of
dermatologists; patient questionnaires and investigator assessments of
changes in scalp hair growth. The effectiveness of Propecia vs. placebo
was demonstrated as follows:
• Hair
count: At the start of the studies, baseline hair counts averaged 876
hairs in a one-inch diameter area of scalp. By the end of the first
year, men taking Propecia had an average of 126 more hairs than men
taking the placebo. This difference continued to grow, and, by the end
of the fifth year, the net difference between the groups increased to
277 hairs in favor of the men taking Propecia. At the end of the fifth
year, 65 percent of men taking Propecia (n=219) maintained or improved
their hair count compared to their hair count at the start of the
studies, while all of the men on placebo (n=15) lost hair count.
Men
treated with Propecia were more likely to say that: their bald spot was
getting smaller and the appearance of their hair had improved, also
that they had experienced increased hair growth.
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Important information about Propecia for use as a treatment for hair Loss
Propecia is not to be used by women or children. Furthermore, women
must not use Propecia when they are, or may potentially be, pregnant as
it may cause abnormalities of the male baby’s sex organs. In addition,
women should not handle crushed or broken tablets when they are
pregnant or may potentially be pregnant.
Propecia tablets are coated, which will prevent contact with the active
ingredient during normal handling provided that the tablets have not
been broken or crushed.
If the treatment does not show results within 12 months, further
treatment is unlikely to be of benefit. If treatment is stopped, the
hair that is gained will gradually be lost.
Propecia hair loss treatment is currently available worldwide.
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